Autophagy inhibition by cudraxanthone D regulates epithelial-mesenchymal transition in SCC25 cells
유수빈, 방태현, 강해미, 박봉수, 김인령,
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유수빈 ( Yu Su-Bin ) - Pusan National University School of Dentistry Department of Oral Anatomy
방태현 ( Bang Tae-Hyun ) - Pusan National University School of Dentistry Department of Oral Anatomy
강해미 ( Kang Hae-Mi ) - Pusan National University School of Dentistry Department of Oral Anatomy
박봉수 ( Park Bong-Soo ) - Pusan National University School of Dentistry Department of Oral Anatomy
김인령 ( Kim In-Ryoung ) - Pusan National University School of Dentistry Department of Oral Anatomy
Abstract
Cudraxanthone D (CD) is a natural xanthone compound derived from the root barks of Cudrania tricuspidata . However, the biological functions of CD in human metabolism have been rarely reported until now. Autophagy is the self-degradation process related to cancer cell metastasis. Here, we elucidated the effects of CD on human oral squamous cell carcinoma (OSCC) cells’ metastatic ability. We confirmed that CD effectively decreased the proliferation and viability of SCC25 human OSCC cells in time- and dose-dependent manners. Also, the metastasis phenotype of the SCC25 cell (migration, invasion, and epithelial?mesenchymal transition [EMT]) was inhibited by CD. To further investigate the mechanism by which CD inhibited the metastatic capacity, we detected the relationship between EMT and autophagy in the SCC25 cells. The results revealed that CD inhibited the metastasis of the SCC25 cells by attenuating autophagy. Thus, our findings produced a potential novel agent for the treatment of human OSCC metastasis.
키워드
Autophagy; Epithelial-mesenchymal transition; Oral squamous cell carcinoma; Xanthone
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